Biomolecular Chemistry

Recent Publications

Installation of Trimethyllysine Analogs on Intact Histones via Cysteine Alkylation. Bas J G E Pieters, Jordi C J Hintzen, Yvonne Grobben, Abbas H K Al Temimi, Jos J A G Kamps, Jasmin Mecinović. Bioconjugate chemistry. Mar 2019.

Sequential Prodrug Strategy To Target and Eliminate ACPA-Selective Autoreactive B Cells. Lianne P W M Lelieveldt, Hendy Kristyanto, Ger J M Pruijn, Hans Ulrich Scherer, René E M Toes, Kimberly M Bonger. Molecular pharmaceutics. 12 2018.

Pathogenic variants in glutamyl-tRNA amidotransferase subunits cause a lethal mitochondrial cardiomyopathy disorder. Marisa W Friederich, Sharita Timal, Christopher A Powell, Cristina Dallabona, Alina Kurolap, Sara Palacios-Zambrano, Drago Bratkovic, Terry G J Derks, David Bick, Katelijne Bouman, Kathryn C Chatfield, Nadine Damouny-Naoum, Megan K Dishop, Tzipora C Falik-Zaccai, Fuad Fares, Ayalla Fedida, Ileana Ferrero, Renata C Gallagher, Rafael Garesse, Micol Gilberti et al.. Nature communications. 10 2018.

Stimulus-dependent chromatin dynamics, citrullination, calcium signalling and ROS production during NET formation. Cynthia M de Bont, Werner J H Koopman, Wilbert C Boelens, Ger J M Pruijn. Biochimica et biophysica acta. Molecular cell research. 11 2018.

Autoantibodies to Cytosolic 5'-Nucleotidase 1A in Primary Sjögren's Syndrome and Systemic Lupus Erythematosus. Anke Rietveld, Luuk L van den Hoogen, Nicola Bizzaro, Sofie L M Blokland, Cornelia Dähnrich, Jacques-Eric Gottenberg, Gunnar Houen, Nora Johannsen, Thomas Mandl, Alain Meyer, Christoffer T Nielsen, Peter Olsson, Joel van Roon, Wolfgang Schlumberger, Baziel G M van Engelen, Christiaan G J Saris, Ger J M Pruijn. Frontiers in immunology. 2018.

Terminal Regions Confer Plasticity to the Tetrameric Assembly of Human HspB2 and HspB3. Alice R Clark, Wilma Vree Egberts, Frances D L Kondrat, Gillian R Hilton, Nicholas J Ray, Ambrose R Cole, John A Carver, Justin L P Benesch, Nicholas H Keep, Wilbert C Boelens, Christine Slingsby. Journal of molecular biology. Sep 2018.

LHP1 Interacts with ATRX through Plant-Specific Domains at Specific Loci Targeted by PRC2. Haifeng Wang, Danhua Jiang, Elin Axelsson, Zdravko J Lorković, Sean Montgomery, Sarah Holec, Bas J G E Pieters, Abbas H K Al Temimi, Jasmin Mecinović, Frédéric Berger. Molecular plant. 08 2018.

NETosis, complement, and coagulation: a triangular relationship. Cynthia M de Bont, Wilbert C Boelens, Ger J M Pruijn. Cellular & molecular immunology. Jan 2019.

Recognition of shorter and longer trimethyllysine analogues by epigenetic reader proteins. Abbas H K Al Temimi, Roman Belle, Kiran Kumar, Jordi Poater, Peter Betlem, Bas J G E Pieters, Robert S Paton, F Matthias Bickelhaupt, Jasmin Mecinović. Chemical communications (Cambridge, England). Mar 2018.

Expression of RMRP RNA is regulated in chondrocyte hypertrophy and determines chondrogenic differentiation. Mandy M F Steinbusch, Marjolein M J Caron, Don A M Surtel, Franziska Friedrich, Ekkehart Lausch, Ger J M Pruijn, Wouter Verhesen, Blanche L M Schroen, Lodewijk W van Rhijn, Bernhard Zabel, Tim J M Welting. Scientific reports. 07 2017.

Immune-Array Analysis in Sporadic Inclusion Body Myositis Reveals HLA-DRB1 Amino Acid Heterogeneity Across the Myositis Spectrum. Simon Rothwell, Robert G Cooper, Ingrid E Lundberg, Peter K Gregersen, Michael G Hanna, Pedro M Machado, Megan K Herbert, Ger J M Pruijn, James B Lilleker, Mark Roberts, John Bowes, Michael F Seldin, Jiri Vencovsky, Katalin Danko, Vidya Limaye, Albert Selva-O'Callaghan, Hazel Platt, Øyvind Molberg, Olivier Benveniste, Timothy R D J Radstake et al.. Arthritis & rheumatology (Hoboken, N.J.). 05 2017.

Peptidylarginine deiminase 2 is required for tumor necrosis factor alpha-induced citrullination and arthritis, but not neutrophil extracellular trap formation. Mandar Bawadekar, Daeun Shim, Chad J Johnson, Thomas F Warner, Ryan Rebernick, Dres Damgaard, Claus H Nielsen, Ger J M Pruijn, Jeniel E Nett, Miriam A Shelef. Journal of autoimmunity. Jun 2017.

Coiled-Coil-Mediated Activation of Oligoarginine Cell-Penetrating Peptides. Saskia A Bode, Ilmar C Kruis, Hans P J H M Adams, Wilbert C Boelens, Ger J M Pruijn, Jan C M van Hest, Dennis W P M Löwik. Chembiochem : a European journal of chemical biology. Jan 2017.

Antibody responses to de novo identified citrullinated fibrinogen peptides in rheumatoid arthritis and visualization of the corresponding B cells. Vijay Joshua, Loes Schobers, Philip J Titcombe, Lena Israelsson, Johan Rönnelid, Monika Hansson, Anca I Catrina, Ger J M Pruijn, Vivianne Malmström. Arthritis research & therapy. 12 2016.

Development and evaluation of a standardized ELISA for the determination of autoantibodies against cN-1A (Mup44, NT5C1A) in sporadic inclusion body myositis. Sabine L Kramp, Dmitry Karayev, Guo Shen, Allan L Metzger, Robert I Morris, Eugene Karayev, Yvonne Lam, Richard M Kazdan, Ger J M Pruijn, Sandra Saschenbrecker, Cornelia Dähnrich, Wolfgang Schlumberger. Auto- immunity highlights. Dec 2016.

Investigating d-lysine stereochemistry for epigenetic methylation, demethylation and recognition. Roman Belle, Abbas H K Al Temimi, Kiran Kumar, Bas J G E Pieters, Anthony Tumber, James E Dunford, Catrine Johansson, Udo Oppermann, Tom Brown, Christopher J Schofield, Richard J Hopkinson, Robert S Paton, Akane Kawamura, Jasmin Mecinović. Chemical communications (Cambridge, England). Dec 2017.

Substrate scope for trimethyllysine hydroxylase catalysis. Abbas H K Al Temimi, Bas J G E Pieters, Y Vijayendar Reddy, Paul B White, Jasmin Mecinović. Chemical communications (Cambridge, England). Oct 2016.

Sputum Anticitrullinated Protein Antibodies in Patients With Long-standing Rheumatoid Arthritis. Ari Polachek, Wilma Vree Egberts, Elizabeth Fireman, Ido Druckman, Moshe Stark, Daphna Paran, Ilana Kaufman, Irena Wigler, David Levartovsky, Dan Caspi, Ger J M Pruijn, Ori Elkayam. Journal of clinical rheumatology : practical reports on rheumatic & musculoskeletal diseases. 04 2018.