Marina Dunaeva

Foto Marina M.Dunaeva[at]
+31(0)24 3615364
Lab 6.15

Master regulators for rheumatoid arthritis

Rheumatoid arthritis (RA) is a complex and multifactorial disease that involves interaction between joint tissues and the immune system. RA is characterized by the infiltration of immune cells in the synovial membrane, the proliferation of synovial fibroblasts, and the destruction of cartilage and bone. Numerous growth factors, cytokines and chemokines mediate these processes.

During RA development and progression, the activation of the immune system leads to broad gene expression changes in many cells including synovial cells causing changes in cellular phenotypes. These phenotypic changes can be characterized by sets of specifically expressed genes. Transcription factors (TFs) play a central role in the regulation of gene expression. Interactions of TFs with their target genes can be represented by gene regulatory networks. A relatively small number of key TFs, referred to as master regulators (MRs), define the function of the regulatory network. They coordinate the dynamic transcriptional responses and cell phenotypes. We apply reverse engineering algorithms to identify MRs that drive phenotypical changes of SFs in RA.


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